Research and Development

Our R&D lab is run by highly qualified professionals. Holders of academic degrees and strong of their many years of practical experience, they ensure Nativa’s advance in the national pharma industry.

Our facilities are vertically integrated, which allows to control the full cycle of production: from pharmaceutical substances to ready-to-use medicine. Today, we focus on developing new medications as well as enhancing the existing ones - for our patients to be offered new, thoroughly tested products at affordable prices.

Our production has up-to date analytical equipment:

Andersen Cascade Impactor (ACI) – by Westech, UK

The ACI is an 8-stage cascade impactor suitable for measuring the aerodynamic particle size distribution. It consists of 8 cascades with openings, retaining plates and a filter.

Every cascade consists of series of openings, through which the tested aerosol sample is suctioned. The particles airflow is directed to the collection surface of every cascade.

Cascade impactor has three unique features:

  1. Detection of aerodynamic size, physical size and form of the particles. This information explains how particles behave in moving air flow (for example, in respiratory tract).
  2. Quantitative detection of active pharmaceutical ingredient (API), which is present in aerosol cloud.
  3. Captures the whole dose to provide the most comprehensive characteristics of tested sample.

Next Generation Impactor (NGI) – by Copley, UK

In 1997, a group of prominent pharmaceutical companies came together in the form of a consortium with the express intent of developing a new impactor specifically for inhaled and nasal products

The result, the Next Generation Impactor (NGI), was launched in 2000 and subsequently accepted into European and US Pharmacopoeias in 2005.

The NGI has seven stages and a micro-orifice collector which acts as a final filter. The impactor works with airflow speed from 30 to 100 l/min. It is made of inert material that doesn’t react with medicine components, for example, aluminum, stainless steel, titanium.

One-step impactor (Glaxo type)

This one-step type of the impactor is not yet added to the USP requirements. The value of the one-step impactor of Glaxo type, relative to QC uses, is nevertheless admitted. These impactors are widely used in testing of pharmaceutical inhaling medicine. It is an ideal device for regular quality control of the production.

Shimadzu laser particle size analyzer

Shimadzu laser particle size analyzer (Japan) is a compact device with high preciseness and productivity. It is used for particle size analysis to control the production of drug for inhalation therapy. The device can control the particle size in a range from 0.1 to 350 µm.

Shimadzu analyzer allows performing simultaneous analysis of up to 12 diagrams, evaluating repeatability and the way characteristics of particle distribution by size change.

Perkin Elmer gas chromatograph

Perkin Elmer automated two-channel gas chromatograph with built-in autosampler for liquid samples and electronic control of gas flows (PPC) is used for routine analysis as well as lab research at capillary and packed columns. Chromatograph and autosampler are managed by a built-in control system with sensor display or by PC. All the parameters are controlled by microprocessor.

Main characteristics::

- Chromatography system has a wide selection of sampling systems, detectors, gas flow control modules and TotalChrom software. Due to these features it is easily adapted to any type of analysis. PerkinElmer chromatographs have the best productivity, flexibility, preciseness, excellent usability because of the unique technological and software features, such as PSS, PPC, PreVent, ProTect, MSVent, GC-Tune, built-in auto-sampler.

- Program control of pressure, flow velocity and linear velocity of the carrier gas, constant volumetric flow rate..

- Unique PreVent device to control the direction of the carrier gas flow in capillary columns. PSS injector, electronic control and PreVent programming of the flow (PPC) increase productivity and make it possible to analyze difficult samples.